The NCIS team investigates the crash of an armored transport bus carrying Naval brig detainees after four prisoners escape, including a black market broker who is one of the country's biggest national security threats. Meanwhile, Pride turns to Gibbs for assistance when a case file needed for the investigation is full of redactions.
The NCIS team investigates the murder of a retired SEAL who tracked down individuals impersonating military personnel. But the case takes a mysterious turn when the lead suspect is found with the Navy-issued jacket of an officer believed to have been killed in the line of duty in Afghanistan. Also, Brody discovers the normally holiday-obsessed Lasalle is inexplicably unenthusiastic about Christmas.
With no memory of the night before, Lasalle’s brother, Cade, turns to NCIS for help when he finds his girlfriend’s body in the trunk of his car. Despite a mountain of evidence that implicates Cade, and the case being under Captain Jim Messier and Jefferson Parish jurisdiction, Lasalle is determined to prove his brother’s innocence.
While Special Agent Pride and the New Orleans team investigate a Russian sleeper agent who was involved with Abby’s brother, Luca, Sebastian flies to D.C. to partner with Abby on the forensics in the case. Also, Bishop drives through the night to deliver a package and work the case with the New Orleans team. The crossover started on NCIS S13E12.
After thousands of classified government files are stolen, the NCIS team searches for an underground group of hackers co-founded by Pride’s old contact, Elvis Bertrand, who are known for exposing corruption among prominent people in New Orleans. Also, Sebastian joins the team as a newly minted NCIS Special Agent.
While investigating a deadly accident at a naval base, NCIS discovers a unit of Seabees was poisoned with a contagious super virus leaving the rest of the base and the entire city of New Orleans at risk for a catastrophic outbreak. Also, during the autopsy, Wade is infected with the virus and given hours to live if an antidote can’t be found.
While Pride remains on probation six weeks after his rogue takedown of the corrupt Mayor Hamilton, his team is closely monitored by Supervisory Special Agent Paula Boyd. Also, when the FBI arrives to run lead on a case involving a stolen big rig of nuclear waste, the team must secretly investigate from the sidelines.
Pride and his team join forces with FBI Director Isler after a Russian operative, who’s in the states to provide intelligence on sleeper agents, disappears after his Navy escort is murdered. Also, Tammy partners with former sleeper agent Eva Azarova to locate the missing operative who Eva has known since childhood.
When journalist Oliver Crane posts a scathing article documenting Pride’s “reckless use of justice,” the team is concerned about the fallout from the piece and the confidential information included in the story. Also, Rita Devereaux warns Pride that someone in D.C. has coordinated this attack on him, and the article is just the beginning.
After Pride’s assistant, Ginny Young, escapes from a kidnapper, the NCIS team uncovers evidence of a suspect who is harvesting organs from multiple victims. Also, Pride turns to his friend, Commander Calvin Atkins, M.D., for medical and spiritual guidance as he struggles with the ramifications of his recent brush with death.
The team investigates the death of a Naval microbiologist whose hobby as a 'myth buster' resulted in his death at the hands of a legendary bayou creature. Khoury conducts an investigation into previous actions of Deputy Director Van Cleef, who recently demoted her for misguided allegations that she exhibited poor judgment.
As New Orleans grapples with the effects of COVID-19, Pride sends Tammy and Carter to investigate a suspicious death aboard a humanitarian ship offshore, where they learn that some crew members are infected with the deadly disease. Also, Wade is overwhelmed by the high volume in the morgue due to COVID-19.
As Tammy and Carter continue to investigate the suspicious death aboard a COVID-infected humanitarian ship offshore, Pride and the team discover that the PPE they were sent to distribute may hold the key to finding the killer. Also, Rita returns to New Orleans to surprise Pride, Wade helps a grieving woman who can't find her brother who died from COVID-19, and Patton and his goddaughter get into a heated argument.
As the NCIS team continue to investigate the murder of an officer who was about to whistle blow on police misconduct within NOPD, Pride must get creative in order to finally get rid of the dirty cops. Also, the Mayor asks Pride to join her new task force to address systemic issues plaguing their city and, as Covid continues to overwhelm the system, Wade finally addresses the toll it's taken on her.
When a Navy therapist with a high level of security clearance is murdered, Pride and the team discover that she was working around the system to get justice for victims of sexual assault. Carter's mother confronts him when he refuses to talk to the FBI for a background check on her behalf. Sebastian starts to form a bond with a key witness who was hit hard by the COVID-19 pandemic.
As Pride and the team continue the investigation of an Officer’s assault and the murder of her therapist, NCIS zeroes in on a prime suspect who’s been working the system for years. Also, Carter and his mother talk about how they’ll move forward after a past mistake, and Sebastian begins a promising new relationship.