Fry, a 20th-century New-York pizza delivery boy receives a prank call and is frozen in a capsule and wakes up in year 2999. He meets an alien named Leela that wants to assign his permanent career... delivery boy. Fry refuses, so he escapes. He then meets Bender, a robot who likes to drink and has suicidal tendencies. Together, they start running away from Leela, arriving to the ruins of old New York. Leela finds them, but instead of inserting the permanent chip on Fry, she removes her own. All three go to Prof. Hubert Farnsworth's house, Fry's only living relative, becoming his new space crew.
After joining Planet Express, Fry, Bender, Farnsworth's assistant Amy and Captain Leela must deliver their first package to the moon. Fry imagines himself walking on the moon, but he finds out that there is an amusement park on the moon - Luna Park. While lowering the package, Amy drops the ship keys inside it. Fry is the only one who wants to walk on the real moon, so he goes with Leela on an educational trip, yet he goes off the road and they are now marooned on the moon with almost no oxygen. Amy and Bender discover that the key that fell inside a crane game machine. Bender is thrown out of the park after putting his hand inside the machine. Fry and Leela arrive at a farm in the middle of the moon where they have to work for oxygen. After Bender sleeps with one of the robo-daughters of the farmer, the farmer starts chasing Fry, Leela and Bender. Amy appears just in time to save them.
Everyone is sick of Fry living at Planet Express, so he is forced to move out to become Bender's roommate. The only catch is that Bender's apartment is too small for the two of them. After some searching they find a great apartment. A problem arises when Bender's antenna interferes with the TV reception. Bender decides to cut off his antenna so that he can live with Fry again. However he doesn't feel right without it, so he decides to leave and go back to his old apartment where he feels lonely. Leela convinces Fry to going back to the "small" apartment.
On a mission intended to save endangered animals on a collapsing planet, Leela and the crew run into legendary starship captain Zapp Brannigan. A self-proclaimed ladies man, Zapp sees Leela as a potential new conquest. When the captain refuses to aid the animal rescue, Leela and her crew try to leave Zapp's starship. But Zapp throws Fry and Bender in jail, and summons Leela to his "Lovenasium". They ultimately escape and arrive on the doomed planet, where Leela finally finds love - with a cute, and very useful, creature named Nibbler.
At Madison Cube Garden watching a blernsball game, Bender complains about the poor treatment of robots. They're only there to clean up, polish the balls or water the fields. They never get any respect. Later, Bender must deliver a package to a planet inhabited by murderous robots that kill humans on sight. He discovers a robotopia - a land where the robot is king! However, when Leela and Fry are captured, Bender must choose between protecting his celebrity status or saving his friends.
A thousand years is a long time to save up money, and Fry's savings account has been racking up interest. When Fry discovers just how much - over 4 billion dollars - Fry goes a little overboard. After completely redecorating the apartment, splurging on expensive spa days and treating his friends to innumerable luxuries, Fry discovers the ultimate expense. Anchovies. This rare delicacy as been extinct for years, and Fry must battle the evil conglomerate known as Mom, plus Pamela Anderson Lee's head in a jar, to get them!
The crew visits an arid planet in the Galaxy of Terror distinctive for it's three suns and liquid alien inhabitants. Fry, after delivering a package under the scorching heat, quenches his thirst with a bottle of cool blue liquid. Fry soon finds out he drank the planet's royal leader and is named the new emperor. Fry abuses his newfound power, even appointing Bender second in command, until the aliens retaliate and the real battle for power begins.
After a string of bad luck, Fry ventures into the decaying ruins of Old New York to regain his lucky seven-leaf clover from his childhood, only to find that his brother Yancy Fry had stolen not only the clover, but Fry's identity as well. Fry sets out to exhume his brother's body, but discovers the startling truth about Yancy instead.
Fry discovers the ability to download any celebrity onto a blank robot, and chooses to download Lucy Liu, with whom he falls madly in love. Repulsed by this disgusting display of human/robot love, Leela, Bender, and Zoidberg set out to shut down Nappster.com and put an end to illegal celebrity downloads forever.
The combined explosions of a supernova and Fry putting metal in the microwave hurtle the Planet Express crew back in time to 1947. They land at Roswell, New Mexico, where a shattered Bender is mistaken for UFO debris, Zoidberg is taken in for an alien autopsy, and Fry accidentally kills his grandfather, Enis, in a nuclear explosion.
Bender receives culinary lessons from the great chef Helmut Spargle, and puts his skills to the test on national television when he competes against Elzar on "Iron Cook". Meanwhile, Dr. Zoidberg accidentally destroys Professor Farnsworth's ship-in-a-bottle and pins the deed on Fry, only to be struck with remorse afterwards.
Dr. Zoidberg's mysterious miracle cream gives Fry and Leela superpowers. Teaming up with Bender, they form the New Justice Team, under the respective alter egos of Captain Yesterday, Clobberella, and Super King. But Leela's new duties as a superheroine put a strain on her relationship with her parents.
When Professor Farnsworth sells Planet Express to the evil Mom, it means she owns over 50% of the Earth, and becomes its supreme ruler. It's up to Fry, Leela and Bender to save the Earth - and the universe - from Mom, as their mission takes them from New New York to alien asteroids, the surface of the sun, the farthest corner of the universe, and even though time itself!
Professor Farnsworth sends the Planet Express to find a statue of his crew for the 50th memorial service honoring their disappearance. They end up going through the Bermuda Tetrahedron and find a ton of lost spaceships - including the original Planet Express! They look around the ship and a 4D whale comes by and eats the old ship and the statue. Leela makes it her mission to kill the whale and get revenge, which makes them late for the memorial. Eventually, the whale eats the Planet Express ship and the whole team. The only person who escapes is Zoidberg, who returns to Earth in an escape pod. While inside the whale, Leela meets the original captain of the ship, Lando Tucker, who is now attached to the whale's stomach. Leela ends up being able to control the whale and steers him back to Earth to attend the memorial. Leela coaxes the whale to spit everything out, including the statue and the original crew and kills the whale.
An episode featuring 3 different segments, in the same vein as episodes such as "Anthology of Interest I" and "The Futurama Holiday Spectacular". Each segment showcases a different style of animation. The first segment will be animated in "a black-and-white Fleischer style", the second segment will be in the style of a low-resolution video game, and the third drawn in the style of anime. The episode is not be canon, and is the final episode of the sixth season of Futurama.
Bender meets his hero, a famous folksinger who has been in jail 30 times, and wants to duplicate his success. This means duplicating his guitar too, which he tries to steal from a maximum-security prison, but fails, so instead resorts to 3D-printing technology to duplicate the guitar — again resulting in horrible consequences.