When an unassuming high school chemistry teacher discovers he has a rare form of lung cancer, he decides to team up with a former student and create a top of the line crystal meth in a used RV, to provide for his family once he is gone.
Walt and Jesse attempt to tie up loose ends. The desperate situation gets more complicated with the flip of a coin. Walt's wife, Skyler, becomes suspicious of Walt's strange behavior.
Walter fights with Jesse over his drug use, causing him to leave Walter alone with their captive, Krazy-8. Meanwhile, Hank has a scared straight moment with Walter Jr..
Walter finally tells his family that he has cancer. Meanwhile, the DEA believes Albuquerque has a new, big time player to worry about. Jesse makes a surprise visit to his parents home.
Walter accepts his new identity as a drug dealer. Elsewhere, Jesse decides to put his aunt's house on the market and Marie throws Skyler a baby shower.
Walt and Jesse are reminded of Tuco’s volatile nature, and try to figure a way out of their business partnership. Hank attempts to mend fences between the estranged Marie and Skyler.
Walt and Jesse find themselves in close quarters with an unhinged Tuco. Marie and Hank comfort Skyler, who is distraught over Walt’s disappearance. Hank pays a visit to Mrs. Pinkman on some not-so-official business.
Walt and Jesse cover their tracks, but as a result, both of their financial situations suffer. Meanwhile, Hank and his DEA colleagues may have a break in their meth investigation.
Walt tries to reconnect with his family. Still suspicious of her husband's actions, Skyler keeps her distance. Jesse finds himself without a place to live and struggles to cope.
Tensions and bills mount at the White household. Hank makes progress at work, but struggles with some residual effects from his encounter with Tuco. Jesse assembles a crew of dealers to get their product out on the streets.
Walt returns to work. Skinny Pete gets ripped off and when Jesse steps in, he gets more than he bargained for. Walt's cover story on how Elliott and Gretchen are paying for his medical treatment starts to collapse.
Rumors fly about Jesse's recent actions as he and Walt discuss expanding their business into new territories. Hank struggles in El Paso. Skyler pursues a new job opportunity. Jesse gets to know his landlord, Jane.
When Badger gets busted, Walt and Jesse seek the legal advice of a shady attorney, Saul Goodman. Hank returns to Albuquerque, but his troubled mental state and demeanor cause Marie to worry.
Walt and Hank get into a fight, and Walt consumes himself with home improvements. Skyler opens up to her boss, Ted. Jane hides her relationship with Jesse from her father.
Walt's lies have pushed Skyler to her limit. Jesse self-destructs after a personal blow, forcing Walt to come to his aid. Donald's grief leads to tragedy.
As Walt copes with the aftermath of the plane crash and Skyler's anger, Jesse comes to a new realization. A new adversary tracks the elusive Heisenberg. Skyler seeks advice on the state of her marriage and confronts Walt.
Gus tries to lure Walt back into business, forcing a rift between Walt and Jesse. Skyler doubts her new relationship. Marie confides in Skyler about her concern for Hank's well-being.
As Walt settles into his new surroundings, Walter, Jr. demands answers about his parents' relationship. Hank's investigation creates an immediate problem for Walt and Jesse.
Hank's increasing volatility forces a confrontation with Jesse and trouble at work. Skyler pressures Walt to make a deal. Gus' actions have severe consequences.
Skyler gets more involved in Walt's business. Hank struggles with his recovery. Jesse takes an active role in his new enterprise, leading him to a startling discovery.
Walt and Jesse face the deadly consequences of their actions. Skyler deals with a puzzling disappearance, as Marie struggles to help Hank with his recovery.
Events spiral out of control at Jesse’s place. Skyler reluctantly asks for Saul’s help. Marie returns to an old pastime and a friend asks Hank for help.
The Cartel takes steps to gain the upper hand. Walt and Skyler share an embarrassing secret with the rest of the family. Jesse’s activities draw unwanted attention.