Police detective Steve Sloan believes that top manager Nick Osborn has killed his boss, trust-owner Russell Cord. His father, senior hospital doctor Mark Sloan, is convinced that his long-time patient Osborn is innocent and soon discovers three other top employees of the Cord Group who also had reasons for killing their boss.
Dr Mark Sloan cannot believe that his former student Dr Drummond, an ambitious cosmetic surgeon, has committed suicide. Assisted by his team of hobby detectives, pathologist Amanda Bentley and junior doctor Jack Parker, Sloan tries to investigate the case.
Dr Sloan suspects that his flame of long ago, famous heart surgeon Dr Rachel Walters, has murdered US Senator Cabot on the occasion of a guest operation at the community hospital.
A Los Angeles earthquake apparently causes an armoire to topple over on top of a good friend of Dr. Sloan's, Martin Garfield, killing him. The dry-eyed Sloan goes to work and discovers that Garfield may have been killed before the earthquake. Jack and Amanda help Mark weed through the wealthy family to find the murderer.
Dr. Sloan's birthday is less than festive when he discovers the body of a prominent divorce lawyer in the Hospital pharmacy. When Steve arrives, the body is nowhere to be found. Mark and Jack work feverishly to find the body, find the culprit, and lead a tour of potential investors all at the same time.
Dr. Sloan is the executor of his friend, Preston Michael's, estate after Michaels is found in the body of a shark. Things turn interesting after traces of poison are found in Michaels' body and three women, all apparently married to Michaels, attend the reading of the will.
A burglar inadvertently becomes infected with a deadly virus. Dr. Sloan and Jesse are subsequently exposed to the virus after Jesse stumbles upon the thief's dead body. Both Mark and Jesse are confined to Mark's home while Steve and Amanda investigate the drug company that manufactured the virus, in the hopes of discovering an antidote before Jesse runs out of time.
This episode takes place four months after Mark was convicted of murder. Steve is slowly recovering from his wounds and Mark is still rotting in prison. While Mark endures the taunts of fellow death row inmate Malcolm Trainor, Steve and Tanis Archer launch a rogue investigation to find Ganza's real killers.
Mark, Steve, Jesse, and Amanda are all trapped in the rubble of Community General in the aftermath of the bombing. Mark tries to shake off the numbing effects of the explosion in time to save Amanda, who's suffering from a punctured lung and broken collarbone. After the dust settles, the hunt for Caitlin Sweeney begins. It's discovered that the Sweeneys belong to a terrorist organization, R.O.A.R.
The hospital is the scene of a manhunt when a corpse comes to life and attacks Amanda, then leads Steve and the police on a chase throughout the entire building during which he kidnaps Jesse's girlfriend Steve. Mark learns the fugitive is on the run from NSA agents, who claim he's an international terrorist.
Steve and his abrasive, confrontational partner are confined to a therapy home for 90 days after Steve shoots and kills a fleeing suspect. Steve's partner, Reggie, believes his wife and daughter are being held hostage by his nemesis, a belief that is furthered by a series of delusional events. On the outside, Jesse and Amanda work with Tanis Archer to solve the murder of a lab technician.
Jesse's car breaks down while he and Susan are on their way to a fun-filled vacation in Carmel. The two are stranded in a small town where Susan spies a supposedly long dead beau, Greg. They eventually discover that he faked his death in order to plunder a shipwrecked vessel undetected. The townsfolk, all in on the scheme, murder Greg and pin the blame on Jesse and Susan.
Newly retired detective Harry Trumble returns to the force when it appears 'The Clown Killer', a murderer Trumble chased for more than a decade, has emerged from obscurity to kill again. Mark is reluctant to help Harry investigate the Clown, in part due to a rift between the two, but also because Mark suspects Harry has something to do with the Clown's reappearance.
Mark, Jesse, and Amanda are trapped in a hotel when it's quarantined after a deadly virus is released. They struggle to contain the virus, while at the same time trying to locate its origin. Meanwhile, a scheming seductress carries out her plan, using the virus as a diversion to rob a nearby bank vault.
Jesse saves a woman, Chloe, in a traffic accident that claims a jealous lover forced her off the road. Jesse looks out for his patient when her ex-boyfriend threatens her. Jesse rushes to Chloe's aid when her life is threatened by her boyfriend, and inadvertently kills him. Jesse finds himself the victim of Chloe's 'fatal attraction' as she pursues him voraciously. It gradually becomes clear that Chloe was the aggressor in her previous relationship.
Steve enlists troubled teenager (he sure looked older than a teenager) Tommy to work as community service at a boxing club after too many brushes with the law. Tommy tries to control his temper. Mark finds that the club's sports drink is drugged, promoting aggressive tendencies in many of the boxers.
The Community General doctors are dragged back into the world of network television when producer Jackson Burley revamps the pilot for Dr. Danger, the television program based on Dr. Sloan. Mark and Steve investigate when Danger's competition, a masked magician who reveals the profession's secrets, is murdered, possibly as a ratings ploy.
Susan Gibney [ Maya ], David Marciano [ Eddie Michaels ], Michelle Stafford [ Trish ], Robert Bailey Jr. [ CJ ], Rusty Burns [ Betsy ], Richard Cody [ Kip ], George W. Hartmann [ Tommy ], William Newman [ Chester Chumley ], Kathleen Lloyd [ Emma Bornstein ], Kevin McNally [ Paramedic ], Aaron J. Meeks [ Dion ], John W. Johnston [ Rick ], Patricia Place [ Mrs. Palmer ], Daniel Zacapa [ Waiter ], Channon Roe [ Lucas (uncredited) ] rc: Med Student Alex Mark's life becomes hectic when a look-alike gangster moves to LA and is caught up in a struggle for power.
In Los Rios enroute to Los Angeles, Carol makes an urgent call to her father, Dr. Mark Sloan, pleading for help. Arriving in the small, seemingly pleasant mountain town, Mark investigates but the whole community denies knowing anything about his daughter and her husband.
Dr. Mark Sloan (Dick Van Dyke) reprises his role as the crime solving doctor in this tv movie based on the television series. When a large group of Mexican workers are infected with a deadly virus, Dr. Sloan and his friends must figure out the cause and cure for it before it's too late.