Secret Service agents Lattimer and Bering are "rewarded" with a transfer to the top-secret Warehouse 13. They meet Artie Nielsen, the caretaker of the mysterious warehouse, who tells them about their new job. The agents are responsible for the collection of every supernatural and unexplained item that the U.S. Government has ever collected. For their first assignment, they are sent to Iowa to investigate a possible artifact belonging to a college student who went berserk and assaulted his girlfriend while chanting an Italian incantation.
In the season two premiere, we pick up right where we left off. MacPherson has blown Artie to smithereens, and disappeared. Is Leena really a traitor? Where has Claudia gone? How will Pete, Myka and the Warehouse fare without Artie? What other havoc did MacPherson wreak when he was alone in the Warehouse? And is there yet a new villain on the horizon?
When an artifact meant for the Warehouse turns up in the small town next door, the team finds themselves in the middle of a B-movie meltdown complete with cowboys, gladiators, sci-fi robots and beach storming marines. Their only chance of survival rests with the man who invented television, Philo T. Farnsworth.
Holiday Special: Pete is hit in the head by an artifact and wakes up to a life where he was never born. Pete must hunt down and persuade the Warehouse team (none of whom recognize him) to go on this life or death mission with him to vanquish a long dead nemesis from the past to get everyone’s lives back.
The Warehouse team struggles with the horrible reality of the Warehouse's destruction and the tragic loss of Steve Jinks, Mrs. Frederic and H. G. Wells. With matters so desperate, Pete, Myka, Artie, Leena and Claudia must decide whether to knowingly use a dangerous artifact for their own personal gain — at the risk of deadly consequences.
Pete and Myka are sent to Philadelphia to find an artifact that is the cause of strange hallucinations — people are fearing monsters, but when attacked, only humans are killed. Artie is searching for more information on what evil he unleashed. Claudia tempts fate as she tries to bring Steve back, with the help of someone unexpected.
When Paracelsus takes control of Warehouse 13, it proves to only be the first step in his plan to recreate the entire world in his image. To stop him, Pete and Myka must follow him back through time to 1541 and prevent him from killing the Regents and becoming the permanent master of the Warehouses.