Case File #34112: ""Dream House"" Blaine and Debbie McCallister summon the Office of Scientific Investigation and Research to investigate the cause of numerous strange occurrences at the site of their new home, after their teenage daughter is hospitalized as a result of a poltergeist encounter. Case File #52111: ""UFO Encounter"" Agents from the O.S.I.R. are summoned to a small town to investigate a double alien abduction of two boys and UFO sightings witnessed by many townspeople.
Case File #321147: ""Perestroika"" The Office of Scientific Investigation and Research's Director of Operations Frank Elsinger orders Case Manager Doyle to lead a team of investigators to Archangelsk in Northern Russia. Having just viewed video footage of a team of Russian scientists examining a creature found frozen in a glacier by two gas plant caretakers, Elsinger does not reveal to Doyle that the last scene of the video showed scientist frightened and pleading for help.
Case File #898750 As the third season begins, physicist Peter Axon is the only remaining member of the Office of Scientific Investigation and Research team. Dr. Anton Hendricks is apparently dead, having disappeared into a mysterious apportation device known as the Arch, case manager Matt Praeger has tendered his resignation after differences with the O.S.I.R.'s Director of Operations Frank Elsinger and senior data analyst Lindsay Donner has left the team after running afoul of Praeger and revealing confidential information. Axon and Curtis Rollins, the case manager assigned to the Arch case, take their investigation to a remote area of northern Quebec after an RCMP officer finds a woman wandering alone in the sub-tundra. It turns out the woman had vanished into the Arch and then re-appeared 2,000 miles away. Lindsay Donner and Matt Praeger rejoin the team to recover Hendricks from the Arch.
Case File #569-977 The Office of Scientific Investigation and Research case manager Matt Praeger is institutionalized after a case goes tragically wrong. Working undercover as an arms dealer in order to gain access to a teenager with ESP Praeger gets caught in the middle of a double cross and apparently fires the bullet that kills the youth.
Case File #659-311 The Office of Scientific Investigation and Research case manager Matt Praeger, security co-ordinator Ray Donahue, chief science analyst Peter Axon and senior data analyst Lindsay Donner visit the scene of a grisly, pre-Halloween murder of two college students who died after having their faces torn off.
Case File #790-002 Matt Praeger's daughter, Dana, is sleeping over at the country home of her friend, Vanessa, when the girls hear a strange noise coming from the bedroom of Vanessa's adopted brother. The Office of Scientific Investigation and Research team arrives at the house to conduct an ""unofficial"" investigation.
Case File #340-872 Archaeologist and former lover of Lindsay Donner finds a 13th century burial shroud inside an ancient Druid coffin. At his request, Donner and the Office of Scientific Investigation and Research team join him in London to verify the authenticity of the ""winding cloth"" and identify the man buried in it.
Case File #500-208 A senior data analyst of the Office of Scientific Investigation and Research dies of an apparent heart attack at a Cuban-style neighborhood party. The rabbi who's conducting the funeral suddenly hears scratching sounds coming from coffin, opens the lid and finds out the man is alive.
Case File #009-873 Two computer programmers trying to develop a solution to the Y2K problem enter a sealed lab and begin work. Later, they go into convulsions and, with blood pouring from their eyes and ears, fall to the ground dead. The Office of Scientific Investigation and Research team arrives at the lab to investigate.
Case File #098-509 Peter Axon and Frank Elsinger run tests on an electromagnetic field (EMF) laser cannon in the lab at Tessler Industries to destroy a missile guidance system. After the experiment fails when the laser device overheats, a janitor resets the cannon and destroys the missile guidance system.
Case File #298-321 Peter Axon is working on a secret project for the Office of Scientific Investigation and Research head Frank Elsinger that seems to have special and very personal significance for Elsinger, who assigns case manager Curtis Rollins to provide security for Axon as he finishes the project, which involves mapping out an anonymous individual's genetic code.