Three best friends from Los Angeles — hopeless romantic Melanie, cynical businesswoman Joy, and aging actress Victoria — are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that the social norms from SoCal no longer apply, and thrilled by their liberating possibilities in Ohio, they decide to celebrate a city that values “real women” and stay where they’re considered “hot.”
Joy tries to take advantage of her newfound appeal in Cleveland by dating a much younger man, but her new relationship ends up exposing an old secret. Meanwhile, Melanie encourages Elka to date again by helping her decide between a bevy of men. Victoria gets hooked on Big N Easy, where she goes for the savings and stays for so much more.
Melanie throws a party to meet their neighbors and she comes off as insulting to one of her next door neighbors (Wayne Knight), a columnist for The Plain Dealer, leading Melanie to fear that he'll write something negative about her. Meanwhile, Victoria gets a offer to do a commercial for underpants in Japan and Elka sports a dyed hairdo that draws criticism from Joy.
A pair of 'magic SPANX' come into the ladies' lives and leads them to unexpected adventures. Joy seeks love, but ends up with a much, much younger man. Melanie wants to catch the eye of a doctor and ends up with all eyes on her. Victoria dons the SPANX for a big audition, but ends up in a major catfight with Melanie Griffith. Elka just wants her team, the Cleveland Indians, to win.
On the day of Elka's wedding, Melanie, Joy, and Victoria wake up with no recollection of Elka's bachelorette party. Flashing back to the night before, the women must gather fractions of their memory to piece together how and when they lost Elka.
A behind-the-scenes look at the season-premiere episode, in which Elka and Mamie's illegal business activities are revealed.
Joy helps Melanie convince Jenna to attend medical school; Victoria obsesses about a nude scene.
Joy and Bob's wedding plans are derailed when they learn there is a baby available for adoption.