Murphy is a hard-living, hard-drinking, disaffected twenty-something with a penchant for cigarettes and casual sex. She’s also blind. Murphy lives with her supportive best friend, Jess, and—more reluctantly—her trusty guide dog, Pretzel, whose presence she resents. Her parents, Hank and Joy, own a guide dog school, a venture they opened hoping it would give Murphy a job with some purpose. Murphy’s closest friend is a sweet teenager named Tyson, whose kindness and intelligence are currently going to waste as he deals drugs on the street for his older cousin, Darnell. Murphy’s life comes crashing down when, while out for a walk with Pretzel, she stumbles upon what she’s sure is the lifeless body of Tyson in the alley outside her apartment. But when the police arrive, including a salt-of-the-earth detective named Dean, there is no body to be found—and with Murphy not exactly sober, the police aren’t especially inclined to investigate. Murphy is devastated, and the only thing holding her back from spiraling downward even further is her resolve to learn what happened to Tyson.
After Murphy’s latest one night stand calls her “Mommy,” she develops a rather unexpected lead in Tyson’s case; Tyson’s mother. Her lead provides rather daunting results so she tracks down Tyson’s cousin Darnell and encounters his “business associate” Max who is immediately smitten with Murphy. Meanwhile, Chloe thinks it’s time for her father Dean to start a dating profile. Lastly, Murphy helps Jess pick out a special gift for her girlfriend Vanessa.
While hanging out with Max in his food truck, Murphy is shocked to hear a familiar voice screaming outside; Murphy offers to watch Chloe so Dean can go on a date, but things get a little crazy after she does the one thing he asks her not to do. Lastly, Murphy's worlds of Max and Darnell and Guiding Hope begin to collide.
Murphy is forced to turn her attention from Max when Guiding Hope's monetary surplus puts them on the radar of IRS agent Josh. Meanwhile, Jess's interest is piqued by a new employee and Felix decides to take matters into his own hands. Dean gets closer to information he can use against Nia and Darnell explores his options.
Murphy seeks to help Max out of a life-or-death situation, while Dean leverages them against each other in an attempt to fix his own bad circumstances. Felix finds difficulty juggling his dating life with his dealing life, while Jess is happily distracted by a new romance. Darnell tries a new gig, but his loyalty to Murphy and Max keeps him entangled in Nia's web.
Murphy's choices plunge the Guiding Hope crew deeper into Nia's game, as Jess continues to grow suspicious of the closed-door meetings between Felix and Murphy. Dean tries to keep Chloe away from Murphy lest she discover the truth about her dad. Pressure mounts as Darnell fails to deliver on his commitment, and Max realizes escaping his prior life is even harder than he thought.
Murphy seeks to help Max out of a life-or-death situation, while Dean leverages them against each other in an attempt to fix his own bad circumstances. Felix finds difficulty juggling his dating life with his dealing life, while Jess is happily distracted by a new romance. Darnell tries a new gig, but his loyalty to Murphy and Max keeps him entangled in Nia's web.
Murphy’s preoccupation with helping Max – whose luck continues to spiral – forces her to take more extreme risks. Felix is forced to contend with issues at Guiding Hope, while Jess struggles as all her relationships are tested. Meanwhile, Chloe meets Dean’s new partner, Gene, who shares information that feeds into her growing suspicions about her father.
Murphy copes by distracting herself with a new motivation: getting even. Felix attempts to help her find other ways to deal with her emotions, but like anything with Murphy, it’s an uphill battle. Josh is smug as he slowly puts together how the night unfolded, until he realized that it’s not over yet.