Lucas Amato, a biology teacher at Meridiana High School, was walking down the streets and he saw a big man dissapper.Then Lucas finds a tube with a glowing green ooze,and takes it home with him. The next night in Lucas's apartment,a woman in black named Cybersix urgues with Lucas to give back the ooze called Sustenance.But before she has a chance to get it,a big strange man much like the one lucas saw the other night,breaks into the apartment. Thw question is, who is Cybersix and where did she come from????
Cybersix is a woman created by a mad scientist named Von Reicher.He has send one of his creations named Data 7 who is a panther,to kill Cybersix. In the day time Cybersix has disguised herself as a male teacher named Adrian Seideman.They have sent him/her to the same school that Lucas works in. During the day, Adrian sees a child pickpoceting.She catches the child and finds out that the boys name is Julian.Julian is forced to steal by an organization underground,and Cybersix is going to get him out of it. Data 7 is still on the look out for Cybersix,but once he finds her,he remembers that he is her brother,and now he fights by her side,to destroy Von's monsters.
Lori bumps into Jose and accidentally gets her walkman's CD switched for the CD-ROM he's using to program his tunneling robot that's going to bdig intot he city's treasurery. When he realises the mistake he sends the Fixed Ideas to get her and the CD. When Lori doesn't show up in Adrian's class Cybersix goes looking for the missing teenager and they wind up working together to stop Jose
Cybersix is attacked by four goblin-like creatures that seem to fear the light. The next night, Cybersix is attacked by eight of the creatures. Julian finds the creatures hiding in the subway and figures out that every morning, each lays one egg that hatches by night. Cybersix, Data 7, and Julian form a plan to get rid of the creatures using the eggs as bait.
Von Riecher sends Jose a gift, a strange egg. The egg hatches into a floating eye that can absorb the souls of people who look directly at it. Jose takes the eye to the city and soon as the entire city (Excluding Cybersix) soulless. With the eye grown to a huge size, Cybersix must find out how to destroy it.
A living island created by Dr Von Reichter begins making its way to Meridina harbour and he tells Jose that its programmed to explode once it arrives. Jose is furious because he wanted to rule Meridiana but his ""father"" tells him he's tired of his many failures and wants to wipe the slate clean but first he wants to conclude matters with Cybersix. Realizing what's going on Cybersix reveals her identity to Lori (who tells Lucas) before heading off to Von Reichter's seaside mansion to face her creator. He tells her he's impressed by the potential she's shown and offers to free her from her dependance on the ""sustainance"" fluid if she serves him. When she refuses he releases his creatures but inspired by Cybersix's rebellion they turn on him. Cybersix manages to divert the island from Meridiana and it arrives at and destroys the mansion while she's fleeing the grounds. Is this the end of Cybersix