Raised by his mother, Rhoda, a high school teacher. Phifer's acting career began when he auditioned at an open casting call for director Spike Lee's Clockers and was selected for the leading role. Working alongside Harvey Keitel and Delroy Lindo, he garnered critical acclaim for his compelling performance as Strike, a young New Jersey drug dealer involved in a murder cover-up. Following his impressive screen debut, he appeared in the comedy spoof High School High.
| Movie | Puff, Puff, Pass | 2006 |
| Movie | Business as Usual: The Exploitation of Hip Hop | 2011 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Episode |
On Air With Ryan Seacrest 3/10/04 |
2004 |
| Episode |
Love, Victor Agent of Chaos |
2022 |
| Episode |
Lie to Me Blinded |
2009 |
| Episode |
Homicide: Life on the Street Blood Ties (1) |
1997 |
| Episode |
Love, Victor Close Your Eyes |
2021 |
| Episode |
Homicide: Life on the Street Control |
1996 |
| Episode |
Love, Victor Day One, Take Two |
2021 |
| Episode |
The Wendy Williams Show Divergent |
2014 |
| Episode |
MADtv Episode #806 |
2002 |
| Episode |
Homicide: Life on the Street Fallen Heroes (1) |
1998 |
| Episode |
Love, Victor Fast Times at Creekwood High |
2022 |
| Series | Late Night with Conan O'Brien | 1993 |
| Episode |
Psych Let's Doo-Wop It Again |
2012 |
| Episode |
Curb Your Enthusiasm Lewis Needs a Kidney |
2005 |
| Episode |
Chelsea Lately Mekhi Phifer |
2009 |
| Episode |
Chelsea Lately Mekhi Phifer |
2014 |
| Episode |
Inside Dish with Rachael Ray Mekhi Phifer |
2004 |
| Episode |
The Ellen DeGeneres Show Melina Kanakaredes/Mekhi Phifer/Jem |
2004 |
| Episode |
Punk'd Mike Shinoda, Brandy, Mekhi Phifer |
2004 |
| Episode |
The Ellen DeGeneres Show Paris Hilton/Kathy Hilton/Mekhi Phifer/ Rhoda Phifer |
2005 |
| Episode |
Love, Victor Perfect Summer Bubble |
2021 |
| Episode |
Lie to Me Sacrifice |
2009 |
| Episode |
Love, Victor Sincerely, Rahim |
2021 |
| Episode |
Love, Victor The Gay Award |
2022 |
| Episode |
Love, Victor The Morning After |
2021 |
| Episode |
Curb Your Enthusiasm The Ski Lift |
2005 |
| Episode |
New York Undercover The Smoking Section |
1995 |
| Episode |
Husbands The Straightening |
2012 |
| Episode |
Love, Victor The Truth Hurts |
2020 |
| Episode |
New York Undercover Tough Love |
1996 |
| Episode |
Save Our History Voices of Civil Rights |
2005 |
| Episode |
Love, Victor What Happens in Willacoochee… |
2020 |
| Episode |
Love, Victor Who the Hell Is B? |
2020 |
