Raised by his mother, Rhoda, a high school teacher. Phifer's acting career began when he auditioned at an open casting call for director Spike Lee's Clockers and was selected for the leading role. Working alongside Harvey Keitel and Delroy Lindo, he garnered critical acclaim for his compelling performance as Strike, a young New Jersey drug dealer involved in a murder cover-up. Following his impressive screen debut, he appeared in the comedy spoof High School High.
| Movie | Puff, Puff, Pass | 2006 |
| Movie | Business as Usual: The Exploitation of Hip Hop | 2011 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Episode |
Love, Victor The Gay Award |
2022 |
| Episode |
Love, Victor Agent of Chaos |
2022 |
| Episode |
Love, Victor Fast Times at Creekwood High |
2022 |
| Episode |
Love, Victor Sincerely, Rahim |
2021 |
| Episode |
Love, Victor Day One, Take Two |
2021 |
| Episode |
Love, Victor Perfect Summer Bubble |
2021 |
| Episode |
Love, Victor The Morning After |
2021 |
| Episode |
Love, Victor Close Your Eyes |
2021 |
| Episode |
Love, Victor Who the Hell Is B? |
2020 |
| Episode |
Love, Victor What Happens in Willacoochee… |
2020 |
| Episode |
Love, Victor The Truth Hurts |
2020 |
| Episode |
Chelsea Lately Mekhi Phifer |
2014 |
| Episode |
The Wendy Williams Show Divergent |
2014 |
| Episode |
Husbands The Straightening |
2012 |
| Episode |
Psych Let's Doo-Wop It Again |
2012 |
| Episode |
Lie to Me Sacrifice |
2009 |
| Episode |
Lie to Me Blinded |
2009 |
| Episode |
Chelsea Lately Mekhi Phifer |
2009 |
| Episode |
The Ellen DeGeneres Show Paris Hilton/Kathy Hilton/Mekhi Phifer/ Rhoda Phifer |
2005 |
| Episode |
Curb Your Enthusiasm The Ski Lift |
2005 |
| Episode |
Curb Your Enthusiasm Lewis Needs a Kidney |
2005 |
| Episode |
Save Our History Voices of Civil Rights |
2005 |
| Episode |
Inside Dish with Rachael Ray Mekhi Phifer |
2004 |
| Episode |
Punk'd Mike Shinoda, Brandy, Mekhi Phifer |
2004 |
| Episode |
On Air With Ryan Seacrest 3/10/04 |
2004 |
| Episode |
The Ellen DeGeneres Show Melina Kanakaredes/Mekhi Phifer/Jem |
2004 |
| Episode |
MADtv Episode #806 |
2002 |
| Episode |
Homicide: Life on the Street Fallen Heroes (1) |
1998 |
| Episode |
Homicide: Life on the Street Blood Ties (1) |
1997 |
| Episode |
New York Undercover Tough Love |
1996 |
| Episode |
Homicide: Life on the Street Control |
1996 |
| Episode |
New York Undercover The Smoking Section |
1995 |
| Series | Late Night with Conan O'Brien | 1993 |
