Eleven-year old genius and kid-scientist Anne has invented and built her own amazing androids. Nick discovers Anne's secret junkyard laboratory and enlists the help of Shania to befriend Anne and her mechanical companions. Together they help solve Anne's scientific problems through real-life solutions.
Shania wants to form a garage band with her brothers but they're not very interested (or very good). Meanwhile at the junkyard, Anne and Nick work on upgrades to the security system. When they put Shania in charge of android-sitting, she finds out they have hidden musical talents and together they create a Garbage Band.
Eyes discovers a butterfly in the junkyard and wants to learn to fly, so Anne, Nick and Shania experiment with different ways to help Eyes off the ground. After several attempts with wings and helicopter blades, they discover that helium balloons are the best solution. That is, until the balloons lift Eyes over the junkyard fence and into the neighbor's yard.
Shania is stuck at home taking care of her little brother Garth while Anne and Nick build a rainbow maker with a prism. Unfortunately, while Anne and Nick are busy, the prism accidentally sails over the junkyard fence when Hand and Eyes are playing monkey in the middle with Pal. The prism ends up in Garth's sticky hands. Hand throws Pal over the fence to retrieve it and Shania's got to help Pal get the prism back before anyone discovers the android in the house.
Anne experiments with growing plants but her crafty robo-mouse eats her experiment. Nick, Anne and Shania devise ways to catch the robo-mouse while the androids discover a stray cat in the junkyard. Hand, Eyes and Pal hilariously try to apply what Anne says about plant-care to taking care of the cat. But once Anne shows them that animals have different needs than plants, they take better care of the cat and want to keep her. Nick realizes the cat is the perfect solution to Anne's plant problem but, unfortunately, the stray has already moved on. Now the question is, will the cat come back?
Anne has recreated Nikola Tesla's plasma ball for her summer school project. Before they can get Anne's plasma ball up and running, the power goes out in the junkyard. Anne decides to try alternative types of energy (sun, wind and people power) to generate electricity for her Plasma Ball. Meanwhile, thanks to Shania's fixation on a popular singer, Hand develops an interest in the electric company truck that comes to fix the power lines... can androids feel love too?
Nick's best friend Zack comes over for a sleepover when Anne is in the middle of an experiment on magnetism. Nick tries to convince her to let Zack come help, but Anne doesn't want anyone else to know about the androids. However, when Pal accidentally gets turned into a magnet, Zack gets drawn across the street into the junkyard due to his metal backpack. Luckily, Zack is pivotal in demagnetizing Pal and becomes the newest member of their junkyard crew.
When Hand acts out of control, Anne, Nick and Shania wonder if it's possible she's throwing temper tantrums or if she's been infected by a computer virus. As they try to figure it out, Hand acts increasingly dangerous and Anne's Dad tells them to shut Hand down. Finally, the kids discover Hand wasn't out of control but was being manipulated by Shania's family's new remote control toy! Now the only question is, how can they get Hand back to normal?
Anne is thrilled when a meteorite lands nearby because the space rock is the last one she needs for her extensive rock collection. Fortunately, Eyes was tracking it in the sky and knows exactly where it landed. Nick convinces Anne to let Eyes come on their space rock adventure but, little does he know, other amateur geologists and Nick's Reporter Mom are on the meteorite hunt too!
With school starting, Anne, Nick and Shania test a rocket messenger system so that they can stay in touch during the school day. They quickly realize that they need something smarter than a rocket to be able to carry messages. Using supplies around the junkyard, the kids turn an ordinary pigeon into a bionic flying delivery system.
It's the first day of school and Nick is nervous about making new friends. Luckily he meets a girl named Charlie who shares his love of science. Meanwhile, Pidgely is on his first "Harrier Pigeon" mission to deliver a message to Nick and Shania, but when he misses the designated time to meet up with them, he has to get resourceful.
Anne, Nick and Shania are babysitting Shania's little brothers when Pal discovers that Meow Cat has had kittens. Shania's super excited and takes one of the kittens away, but quickly learns this was a bad idea. When she tries to return the kitten, Meow Cat has moved and taken the other kittens with her. The kids have to find Meow Cat and return the kitten to its Momma before it's too late.
When Nick's Dad bails on a Father/Son Science Center Challenge at the last minute, Anne lets Nick borrow her Dad. While Nick and Anne's Dad do some male bonding as they try to figure out how to make the fastest mini-vehicle without wheels, Anne, Shania and Nick's Mom do some female bonding with a girls' day.
Anne gets an assignment from school that instructs her to "get closer to one of her dreams." She's not sure what it means, but Nick and Shania help her figure out that one of her dreams is to make contact with alien life. To help Anne get closer to that dream, they experiment with how to send one of the androids into space.
Anne is planning a series of experiments with dry ice, but her plans are interrupted by an invitation to Charlie's birthday party. At the costume party, Anne is excited to find dry ice so she can finish her project. Meanwhile, Nick and Shania have to keep Charlie from finding out about Pal when Pal decides to tag along.
It's time for the Weld Zone Father/Son Mini-Vehicle Challenge again and, like last year, Nick is planning to participate with Anne's Dad. But, surprise. Nick's Dad shows up at the last minute to compete with Nick. Wilbert steps aside but Nick still ends up needing him when his Dad is less than helpful.