Im Rehabilitationsbereich des Gefängnisses Oz geht ein Probemedikament um, das den Insassen die Zeit hinter Gittern verkürzen soll. Ryan O’Reily weigert sich – sollte das Mittel seine Wirkung erzielen – seinen Bruder Cyril damit in Berührung kommen zu lassen. Der Gefangene William Giles hat um einen außergewöhnlichen Hinrichtungswunsch. Bestürzung macht sich breit.
Despised by both the Latinos and the gangsters, Alvarez snaps and kills another Latino inmate. He's then returned to solitary. McManus continues to argue the problems of the drug experiment. Cyril sudden physical aging scares Ryan. Inmate Wick, one of the bikers who's taken the drug dies suddenly while talking to Hoyt. After officially joining the Muslims, Tidd attempts to kill Said, but decides not to after his conscious gets to him. Still out of control and unpredictable, White stabs McManus in an effort to gain the respect of the other inmates. Johhny Basil gets visited by his former partner who's still angry at him. Supreme Allah returns to Oz and immediately draws Redding's ire. Redding then tells Hill that Allah tipped the cops off, causing Hill's arrest. Hill then confronts Allah about this and Allah beats Hill. Father Ray and Rev. Cloutier finally meet. Schillinger finds out about Hank's death and immediately swears revenge. Keller tells Schillinger that he had Hank killed so Vern won't go after Beecher's family. Keller then gets transferred out of Oz to stand trial in Massachusetts.
Alvarez joutuu takaisin eristykseen. Vanhennuslääkkeen vaikutukset alkavat näkyä. Omar White tekee jotain sellaista, josta hänet huomataan.
O'Reily ressent les effets de la drogue qui accélère le vieillissement. L'expérience est brutalement interrompue après la mort de Wick. Tidd tente de tuer Said mais sa conscience l'en empêche...
רובסון לוחץ על טיד לרצוח את סעיד. היל מגלה מי הלשין עליו לשוטרים ואחראי לתפיסתו.
Desprezado tanto pelos Latinos como pelos gangsters, Alvarez passa-se e mata um outro preso Latino. É então devolvido à solitária. McManus continua a discutir os problemas da experiência com o medicamento. O envelhecimento físico súbito de Cyril assusta Ryan. O preso Wick, um dos motards que tomou o medicamento, morre subitamente enquanto conversa com Hoyt. Depois de se juntar oficialmente aos Muçulmanos, Tidd tenta matar Said mas decide não o fazer quando a sua consciência se faz sentir. Ainda fora de controlo e imprevisível, White esfaqueia McManus num esforço para ganhar o respeito dos outros presos.
Презираемый и латиноамериканцами и гангстерами, Альварез хватает нож и убивает другого латиноамериканского заключенного.
Despreciado por latinos y mafiosos, Álvarez mata a otro preso latino y vuelve a aislamiento. McManus no está de acuerdo con el ensayo clínico. Ryan se asusta al ver el repentino envejecimiento de Cyril.
Alvarez är avskydd både av latinos och gangsters. Han får en knäpp och mördar en annan latino, vilket tar tillbaka honom till isoleringen. McManus argumenterar fortfarande mot drogexperimentet. Cyrils plötsliga åldrande skrämmer Ryan.
