Rentaro und Enju müssen das Level 5 Zodiac-Gastrea "Scorpion" mit Hilfe der "Leiter zum Himmel" ausschalten.
Rentaro and Enju head into the bay area while Kayo stays behind to defend the area from the looming Gastrea. Discovering that all of the other civil officers had been gruesomely slaughtered, Kagetane and Kohina make a stand before the pair. Rentaro charges at Kagetane and breaks through the latter's Varanium barrier with his own Varanium prosthetic limbs. Kagetane then urges Rentaro to join him in starting another Gastrea War. However Rentaro refuses and Kagetane blows a hole through his abdomen. On the verge of death, Rentaro uses Sumire's experimental AGV drug to successfully regenerate his body and then uses his Varanium-enhanced martial arts to viciously defeat Kagetane. Afterwards a Stage Five Gastrea appears outside the Tokyo Area, and Kisara has Rentaro activate the Heaven's Ladder railgun. Unfortunately, various errors force Rentaro to use his own left Varanium arm as a projectile and manually fire the weapon; successfully destroying the Gastrea. In the aftermath, Rentaro discovers Kayo on the verge of death after defending the area for his sake and ends her life coup de grâce. Later, Rentaro accuses Kikunojo Tendo of being the mastermind behind Kagetane's actions.
In the epilogue, Rentaro questions Seitenshi on the origins of the Gastrea however she refuses to disclose any information. Afterwards Rentaro gives Enju the results of her Gastrea corrosion examination which appear normal. Unbeknownst to Enju though, her rate of corrosion far exceeds what Rentaro told her.
Pour récupérer le coffret, Rentarô et Enju devront vaincre Kagetane. Rentarô devra utiliser tous ses talents s'il veut avoir une chance d'y arriver.
Rentaro ed Enju si dirigono nell'area della baia mentre Kayo rimane indietro per difendere l'area dai Gastrea. Scoprendo che tutti gli altri ufficiali civili sono stati massacrati, Kagetane e Kohina si mostrano davanti alla coppia.
29名もの民警たちをあっさりと返り討ちにした影胤と、再び対峙する蓮太郎と延珠。すべてを弾き返す絶対防御の盾として作られた影胤を前に、蓮太郎自らも“真の力”で立ち向かう。殺すために作られ、存在意義の証明のために闘争を望む影胤と、相容れない蓮太郎の激突。しかし、その激しい戦いの決着をあざ笑うかのように、ステージⅤのガストレアが、姿を現した――。
히루코 카게타네와의 마지막 싸움에서 힘겹게 승리를 거둔 렌타로. 하지만 생각지도 못 한 스테이지 5의 출현에 세계는 대절멸의 위기에 빠져 버린다. 세계를 대절멸에서 구해내는 임무를 맡게 된 렌타로와 엔쥬. 두 사람은 가스트레아를 쓰러뜨리기 위해 하늘의 사다리로 향한다.
Hiruko acaba con 29 parejas de oficiales civiles en un instante para volver a verse las caras con Rentaro y Enju. Rentaro le muestra sus verdadera fuerza a Hiruko, dejándole claro que no es la única arma humana.
