Es gelingt Rentaro und Enju das gesuchte Gastrea ausfindig zu machen und die geheimnisvolle Kiste zu bergen. Kurz darauf wird ihnen diese aber schon wieder abgeluchst und Rentaro schwer verletzt.
Enju tries returning to school but meets harsh rejection from her former peers until Rentaro appears and suggests that she transfer elsewhere. At the same time Kisara locates the source of the recent Gastrea infection and immediately dispatches the pair to its location. However after Enju makes quick work of the creature and exposes the case within it, she breaks into tears because of the status quo but Rentaro promises that he will always stand by her. Afterwards Rentaro tries retrieving the case but they are suddenly ambushed by Kagetane and Kohina Hiruko. Rentaro puts up a valiant effort against Kagetane but finds himself severely overpowered by the latter's Varanium powers and mortally wounded by Kohina. Sometime later, Rentaro awakens in the hospital and Seitenshi has him participate in a mission with other civil officers to stop Kagetane from using a catalyst in the case to summon a deadly Stage Five Gastrea with the potential to destroy the Monolith barriers. As the mission gets underway, Rentaro and Enju stumble upon Shogen Ikuma's Initiator: Kayo Senju and Rentaro pleads at her humanity due to the way she follows Shogen's orders to kill without remorse. The trio then follow Shogen's intel to the bay area where the other civil officers intend to attack Kagetane.
Rentarô s'interroge sur la place d'Enju dans la société après que l'école a découvert sa véritable nature. En parallèle, la course pour la récupération de l'Héritage des sept étoiles continue.
Enju cerca di tornare a scuola, ma trova il duro rifiuto dei suoi ex amici, finché non appare Rentaro e le suggerisce di trasferirsi altrove. Allo stesso tempo, Kisara individua la fonte della recente infezione da Gastrea e invia immediatamente la coppia nella sua posizione.
ガストレアウイルスを保持する『呪われた子供たち』だと知られ、学校で孤立してしまった延珠は、悲しみも癒えぬ間に、感染源ガストレアの追跡を余儀なくされる。蓮太郎の目の前で、半ば自暴自棄に戦い、目標のガストレアを倒す延珠。しかし、ケースを手に入れたふたりの元に、またも影胤が現れる。『新人類創造計画』によって生み出された機械化兵士である影胤に一撃で無力化された蓮太郎は、なんとか延珠を逃がし――。
마음을 다잡고 학교로 돌아온 엔쥬였지만 친구들은 차갑게 엔쥬를 외면하고. 엔쥬는 상처받은 마음을 억누른 채 렌타로와 가스트레아 사냥을 떠난다. 힘겨운 싸움 끝에 가스트레아를 무찌르고 칠성의 유산을 손에 넣은 렌타로와 엔쥬. 하지만 카게타네에게 칠성의 유산을 빼앗겨 버리고. 결국 정부는 민경들을 모아 카게타네를 추격을 위한 대대적인 작전을 벌이기 시작한다.
Enju tiene problemas en su escuela debido a la discriminación que sufre por ser una Niña Maldita. Mientras tanto, la fuente de infección de un Gastrea es localizada, provocando que Rentaro y Enju salgan a la acción junto a las demás parejas de Iniciadores.
