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Yes

Lauren Graham as Fran Lockwood (voice)
Cloris Leachman as Gran Crood (voice)
Frank Welker as Azrael (voice)
Seth MacFarlane as Ted (voice)
Jonathan Winters as Papa Smurf (voice)
Bill Hader as Flint Lockwood / FLDSMDFR (voice)
Clark Duke as Thunk Crood (voice)
Jeff Foxworthy as Handy Smurf (voice)
Danny Mann as (voice)
Barbara Jo Allen as Fauna (voice)
Mr. T as Officer Earl Devereaux (voice)
Lori Alan as (voice)
Joel McCrary as Farmer Smurf (voice)
Chris Sanders as Belt (voice)
Angela Shelton as Regina Devereaux (voice)
Emma Stone as Eep Crood (voice)
James Earl Jones as Mufasa
Neil Patrick Harris as Steve the Monkey (voice)
Bob Bergen as (voice)
Tom Kane as Narrator Smurf (voice)
Laraine Newman as (voice)
Neil Flynn as Weather News Network Producer (voice)
Anton Yelchin as Clumsy Smurf (voice)
Cameron Seely as Cindy Lou Who

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