The semifinals continue at the 2010 National Heads-Up Championship, with $125,000 locked up and a place in the final on the line. At the feature table, Scotty Nguyen and Erik Seidel resume their clash of poker heavyweights. Meanwhile, Annie Duke and Dennis Phillips battle on the outer table for the last seat at the championship match.
| Name | Type | Role | |
|---|---|---|---|
| Leeann Tweeden | Host | Herself - Commentator | |
| Craig Hummer | Host | Himself - Commentator | |
| Oliver 'Ali' Nejad | Host | Himself - Commentator |