Semifinal action begins at the 2010 National Heads-Up Championship, with $125,000 secured and just two players away from the $500,000 title. At the feature table, Scotty Nguyen squares off against Erik Seidel in a battle of legends. On the outer table, Annie Duke takes on Dennis Phillips for a spot in the final.
| Name | Type | Role | |
|---|---|---|---|
| Craig Hummer | Host | Himself - Commentator | |
| Leeann Tweeden | Host | Herself - Commentator | |
| Oliver 'Ali' Nejad | Host | Himself - Commentator |