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Rachel House as Gramma Tala (voice)
Russell Brand as Dr. Nefario (voice)
Angelina Jolie as Master Tigress (voice)
Lake Bell as Patrol Witch / Wagon Witch #2 (voice)
Will Ferrell as Megamind (voice)
T.J. Miller as Tuffnut (voice)
Ana Ofelia Murguía as Mamá Coco
Don Rickles as Mr. Potato Head
Jon Hamm as Brogan (voice)
James Coburn as Waternoose
Mike Myers as Shrek (voice)
David Spade as Kuzco / Kuzco Llama
Kathy Najimy as Mary (voice)
Vicki Lewis as Deb (&Flo) (voice)
Andy Samberg as Jonathan (voice)
Andrew Stanton as Crush (voice)
James Cromwell as The Colonel
Pat Carroll as Ursula (voice)
Sandra Oh as Debbie Grayson
Charlie Day as Luigi
Antonio Banderas as Puss in Boots (voice)
Minami Takayama as Conan Edogawa
Jay Baruchel as Hiccup (voice)
Michael-Leon Wooley as Louis (voice)

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