When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
A priest is murdered and the suspect is a nun. It's been rumored that the two of them are having an affair.
An actor rigs a fake on-air shooting with the connivance of his friend, the show's host, but the practical joke goes horribly wrong when the gun, which he'd loaded with blanks, turns out to contain a live round.
An old flame of Mason's is one of those being considered to fill a vacated government position. Her husband's approached by a man who says he knows his wife's secret and if this secret ever gets out, her appointment might not push through.
Jordan White, a publisher friend of Perry's, is called to a hotel. Meanwhile, David Hall, a famous horror writer, has invited "friends" to the hotel to discuss business.
Perry and Della are invited to meet Suzanne, the new wife of a man Della used to babysit.
Perry is suing a gutter trash newspaper that is running a story about a love affair between him and Della.
Air Force Lt. Col. Kevin Parks was arrested and convicted for a murder of a woman. During his second appeal, a new witness is murdered.
A tennis player is accused to having killed his wife, a rich heiress. The facts are against him as he was seen in the arms of his former girlfriend the night before the murder.
Ken Malansky is a law student attending a class being taught by Perry Mason. When a friend tells him that his girlfriend was assaulted by a fellow student, Ken rushes to the university’s mock courtroom to confront him and finds him dead. The murder weapon was Ken’s own knife. Perry is reluctant to take on his case, especially since the victim was the son of a close friend.
Perry Mason defends a young theater director accused of killing a famous Broadway musical director.
Bobby Spencer is a hockey player. After being injured, he threatens Thatcher Horton, the team’s owner, who promised to take care of him.
The chief suspects of an author’s murder are the numerous colleagues whom he continuously plagiarized.
Perry Mason defends the son of an old friend who is accused of killing an ex-officer of the Nazi-SS.
Perry Mason defends the husband of a famous pop singer who was found shot to death after having had an argument with her husband who was also her manager.
A teenager from Las Vegas asks Perry Mason to defend her father who is accused of killing a man blackmailing him.
Perry is at TV station "KGGY" to be interviewed but thanks to the interference of anchorman Brett Huston, the interview is canceled.
A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...
David Katz, a world famous magician, comes to Denver to perform at a charity gala for disabled children.
Dyan Draper, an editor of a well known fashion magazine, is infamous for writing columns that destroy other people’s career. Lauren Jeffreys, the editor of another magazine, meets with Dyan in an attempt to get Dyan not to write about her in her next column.
A painter, who faked his death so his paintings would appreciate in value, reappears when forged paints accredited to him show up in an art gallery.
Sleazy talk show host, Ted Mayne, writes a tell-all book, which enrages and embarrasses several very prominent women.
Perry Mason is invited to the marriage of an old friend’s daughter. Before the end of the ceremony, the uncle of the groom is found dead.
The owner of a cosmetics company is unveiling a new cream which she claims she’s been using. She’s been keeping her age a secret and now reveals that she’s 60 and owes her appearance to the cream.
Dr. Sheila Carlin, a radio talk show host, asks Perry for help to find out who’s harassing her.
Actress Kris Buckner is being forced off a popular daytime soap opera by co-star Mark Stratton. When she threatens him, she makes herself the prime suspect of Stratton’s murder.
Attorney Anthony Caruso, an old friend of Perry Mason's, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives.
When Perry is unable to deliver a speech at a conference, he asks Bill McKenzie to cover for him. Meanwhile, Daniel Kingman, a famous chess player and a friend of Bill’s, is being filmed as a guest on an episode of "Lifestyles of the Rich and Famous".
Perry's secretary Della and private investigator/lawyer Ken go to visit an old friend, rancher and famous lawyer, "Wild" Bill McKenzie. Meanwhile, gubernatorial candidate Harlan Richards is murdered, and his daughter, Karen, thinks that Harlan’s rival, Governor Ryan Allison, has something to do with her father’s death.
Bill McKenzie's niece works as a production assistant for controversial television personality Josie Joplin, who publicly accuses her of having an affair with her husband. One night McKenzie's niece receives a message which she believes is from Josie to go to her hotel room. When she gets there someone knocks her out and when she wakes up, Josie is dead and she's the number one suspect.
Rich business man Mr Gordon has many enemies and a family that wouldn't miss him if he dropped dead. Someone hires a hitman to kill him and it is carried out in such a way to frame Gordon's secretary Della Street. When Della is accused of the murder, Perry mason resigns his position as judge to defend her and employs the son of his old colleague, Paul Drake, the act as private investigator on the case.
