The Round of 32 begins at the 2011 National Heads-Up Championship as big names collide for a shot at the $750,000 top prize. Doyle Brunson battles Dennis Phillips, while Chris Moneymaker faces Dan Cates in a clash of generations. Other marquee matchups include Carlos Mortensen vs. David Oppenheim, Patrik Antonius vs. Eugene Katchalov, Olivier Busquet vs. Liv Boeree, Jason Mercier vs. Andy Bloch, Barry Greenstein vs. Ayaz Mahmood, and Jonathan Duhamel vs. Antonio Esfandiari.
| Name | Type | Role | |
|---|---|---|---|
| Oliver 'Ali' Nejad | Host | Himself - Commentator | |
| Craig Hummer | Host | Himself - Commentator | |
| Leeann Tweeden | Host | Herself - Commentator |