The Hearts bracket takes the spotlight in Round of 64 action at the 2010 National Heads-Up Championship, with players eyeing the $500,000 top prize. At the feature table, poker legends collide as Howard Lederer faces off against Phil Hellmuth. Outer table matchups include Jesper Hougaard vs. Allen Cunningham, Doyle Brunson vs. Brock Parker, Kara Scott vs. Dennis Phillips, J.P. Kelly vs. Don Cheadle, Eli Elezra vs. Greg Mueller, Annette Dworski vs. Chris Ferguson, and Annette Obrestad vs. Orel Hershiser.
| Name | Type | Role | |
|---|---|---|---|
| Craig Hummer | Host | Himself - Commentator | |
| Leeann Tweeden | Host | Herself - Commentator | |
| Oliver 'Ali' Nejad | Host | Himself - Commentator |