The American government hires Golgo 13 to eliminate a Syndicate-established hideout where poisons from various animals are weaponized by the CIA. However, another assassin named AX-3 is also hired out to do the same thing Golgo was suppose to do. AX-3 is eventually killed when his handler informs him of his orders to eliminate Golgo 13.
条約違反の毒物を扱っていた組織が、証拠隠滅のため関係者の抹殺を計画。組織の依頼を受けたゴルゴ13は、毒物製造工場のあるパラオ諸島へと向かう。だが島では、同じ標的を狙うもう一人のプロがすでに活動を開始していた。