Two-hour pilot: Three attractive young women – Marcy Bower, Pam Bellagio, Lisa Benton – succeed in qualifying for airline stewardess training, become fast friends as they manage to complete the tough course at Sun West Airlines Training Centre based in Los Angeles, and then start getting a taste of the rigors and fun of the real thing as rookie stewardesses, as well as getting the attention of womanizer Captain March. Meanwhile, waiting for them up in the air are Burt Stahl, a passenger relations representative for Sun West Airlines, and Paul Mitchell, a shy but love-hungry psychologist: Burt is trying to help Paul recover from the emotional wounds of a divorce by working his way through all the new crop of stewardess trainees alphabetically starting with the B-girls – Bellagio, Benton and Bower – and promises that if Paul surveys the trainees, he will fix him together with whichever girl strikes his fancy.
Lisa, Marcy and Pam and the passengers get stuck in a pilotless plane spinning out of control because the entire cockpit crew are ill with gastric pains after consuming poisoned cheesecake and the stewardesses must take control of the situation; meanwhile, Lisa learns that the cheesecake she fed the pilots was contaminated.
A prisoner, taken in custody, sets himself free from his guard and takes Marcy as a hostage on her flight; meanwhile, Pam and Lisa find themselves at the mercy of a noisy group of wild conventioneers on a stay at a San Francisco hotel.
Pam, Marcy and Captain March are involved in a pursuit with the FBI when they mistakenly take the wrong briefcase left on the airplane containing strictly confidential papers which belong to a newspaper reporter; meanwhile, Lisa finds romance with a smooth-talking presidential candidate.
Pam and Lisa must cooperate with a defector from the Soviet Union and a tyrannical senior flight attendant on her last pre-retirement run; meanwhile, Marcy becomes coach of a baseball team and the coach of the opposing team is Captain March.
Pam and Marcy are assigned on the flight to Miami but due to bad weather conditions, the jet is deviated to Georgia where they must spend Halloween night at a haunted hotel; meanwhile, Lisa attends a fashionable Halloween party in Connecticut and falls in love with an older, rich playboy.
Pam, Lisa and Marcy's flight to Los Angeles is filled with unusual travelers: a blind passenger, a nude medical student, a fear-crazed passenger, a stowaway and Pam has a surprise reunion with an old flame whom she later suspects of being a jewel thief when a diamond pendant is missing from an old socialite on the plane.
Marcy's new friend Greg turns out to be a drug smuggler who tries to convince her to become his accomplice and asks that she carry a package of opium from Mexico into the USA; when Marcy tells Captain March, the girls and the police about it, they pretend to be involved in the deal to help police break the drug-smuggling ring.
Marcy, Lisa and Pam are incensed when they discover that an advertising woman executive at Sun West Airlines suggest that they wear jauntier uniforms to represent a better image to the airline; Captain March and a male flight attendant are busy revving up the old charm and charisma to land themselves in the advertising blueprint.
The girls visit Las Vegas where Pam befriends an elderly retired dentist who tells her that his psychiatrist son from Beverly Hills wants nothing to do with him and Pam shows understanding for the old man's grief; meanwhile, a Las Vegas nightclub star pursues Lisa and Marcy wins at the casino.
The girls visit a resort in Palm Springs for a romantic weekend; while Lisa is helping Captain March try to keep his neck out of the bone-crushing grasp of a jealous boyfriend, Pam is trying to figure out what to do about the ardent attention of a teenage suitor.
Pam is sent to attend stewardesses training school for temporary duty where she meets the spoiled daughter of a Sun West Airline executive and a scandal will lead the two women to clash; Marcy is startled to learn that the lone passenger on her flight is a very peculiar young multi-millionaire.
Captain March attends his high school reunion in San Francisco with Pam, Lisa and Marcy; at the toga party, March is reunited with his ex-girlfriend Candy who is engaged to his old friend Reggie, a fast-talking girlie magazine publisher, and when Candy's love for March is aroused once more, she feels insecure about whom she should marry.
Marcy and Lisa struggle to reunite Billy Bob and Essie Mae, an estranged married couple who are Marcy's old schoolmates; Billy Bob arrives in Los Angeles, locates Marcy and proposes marriage to her, and Marcy is surprised when ugly-duckling Essie Mae shows up and turns out to be Billy Bob's sweet, but neglected wife.
Captain March, who is suffering from temporary blindness due to a sport injury, takes full advantage of the girls when they offer to help him recover at their apartment, but when they discover that he is only simulating, they plot revenge on him; Marcy must face pilot Bill who turns to blackmail because of her unauthorized moonlighting.
Lisa and Marcy are mistakenly arrested as prostitutes in San Francisco; Captain March is reunited with an old Air Force buddy who has undergone a sex change and is now an attractive woman while the girls drop in on old friends who have also undergone significant changes over the years.
Captain March collides at the airport with a woman who proceeds to sue him for $2 million because she has become frigid since the accident; the woman turns out to be Pam's friend and Pam suspects that her frigidity is triggered by her fiancé.
The girls find out independently that they have complexes and, determined to confront their weaknesses, they choose the same training place - a nudist's camp - where they find themselves embroiled in all kinds of embarrassing situations; Captain March has to abstain from womanizing for an entire weekend if he wants to get a date with Lisa.
On her flight to Los Angeles, Pam becomes friendly with TV star Rod Hunter and, unlike the tough policeman he plays on screen, Rod is in reality charming and courteous; meanwhile, a pregnant woman begins to undergo labor pains.