Zwei Menschen mit ganz unterschiedlichen Charakteren sind in Shanghai auf der Suche nach einer guten Story: der erfahrener Klatschreporter Minoru Minorikawa und die junge Fotoreporterin Maria Ôsawa.
Maria Ōsawa and Minoru Minorikawa are dispatched to Shanghai from Japan, two years after the events of 428: Fūsa Sareta Shibuya de, to cover the upcoming International Anti-Terrorism Conference in the city with various world leaders coming to attend the meeting. Canaan, a Middle Eastern teenaged mercenary, was in the city as well after meeting with the unknown female contact with information that her rival Alphard was captured and secretly detained in Karachi, Pakistan by covert operators of the CIA's Special Activities Division. When Maria comes to see an unknown man dead with the Ua virus, Canaan saves her from being assassinated by masked gunmen before she defeats the rest of them without alerting and panicking the public with heightened senses in synesthesia. Meanwhile, the CIA's SAD convoy comes under attack from an IED ambush while transporting Alphard in their custody.
Mino, un reporter japonais est envoyé à Shanghai pour écrire des articles de faible intérêt. Il est accompagné de Maria Osawa, une photographe débutante. Alors que Shanghai est en pleine célébration, une mercenaire se met au travail : Canaan...
魔都・上海。そこで行われている祭りを、ビルの屋上から見下ろす少女の姿があった。名はカナン。一方、寂れた漁港に降り立つ、犯罪組織「蛇」のボス・アルファルド。そして駆け出しのカメラマン大沢マリアも又、フリー記者の御法川と共に同地に降り立っていた。三人の女性が揃った今、運命が動き出す!
Maria Osawa y Minoru Minorikawa se envían a Shanghai de Japón, dos años después de los acontecimientos de 428: de Shibuya , para cubrir la próxima Conferencia Internacional contra el Terrorismo en la ciudad con varios líderes mundiales que vienen a asistir a la reunión.
魔都·上海。在那里正举行着庆典,少女的身影在那建筑物的屋顶上俯视着,她名为迦南。另一方面,在一个凄凉的渔港,犯罪组织“蛇”的头目阿尔珐尔德出现在那里。然后初出茅庐的摄影师大泽玛利亚,与自由记者御法川一起降落在了这里。三位女性一齐出现了,命运开始动起来。