As Wolf deals with a personal crisis that brings up dark corners from his past, the interns assist an MMA fighter exhibiting strange symptoms. Meanwhile, Pierce is visited by Bitsy, an Upper West Side housewife with a penchant for gossip, who gives her some shocking intel about a nearby influential surgeon.
When a college student comes in with a life-threatening illness, Dr. Wolf and his team have to get acquainted with sorority life. Dr. Thorne treats a child who collapsed under mysterious circumstances.