On their way home from a family party, David (Luke Wilson) and Amy Fox (Kate Beckinsale)--who are on the verge of divorce after a family tragedy drove them apart—take a wrong turn on a remote mountain road. Once their vehicle ceases working, they discover there is no cell phone reception and start walking back to a motel across the street from an auto repair garage they had stopped at earlier. Oddly, when they arrive, there are no cars in the parking lot. At the office, they hear piercing screams coming from the back room. The motel manager, Mason (Frank Whaley), appears and explains that the noises are coming from the television. They book a room for the night.
Set three years before the first film, the action takes place in and around the Meadow View Inn, a small roadside motel in rural North Carolina. It opens with newlyweds driving and the bride wants to have sex in the car, which makes the groom stop. They are then stopped by a man, whose property they are on, so they head to the motel. The manager, Gordon (David Moscow), oversees an operation of using cameras within the motel to videotape the newlyweds having sex.