The series chronicles the rocky coexistence of Larry Appleton and his distant cousin Balki Bartokomous. A Wisconsin native, Larry, who comes from a large family with numerous brothers and sisters, has just moved into a new apartment in Chicago, and is experiencing his first joys of newfound privacy when Balki, a hitherto unknown cousin from a Greek-like island in the Mediterranean called Mypos, drops by to live with him. Balki, a shepherd by trade, interprets what little he knows about the United States by relying on his own recollections of American pop culture, which are often out-of-context. After initially gently rebuffing his cousin's request to stay at his apartment, Larry, an aspiring photographer, decides to take Balki under his wing and teach him about American life...
The Winslows, a middle-class Black family living in Chicago, deal with various misadventures — many of which are caused by their pesky next-door neighbor, ultra-nerd Steve Urkel.