Lou Gehrig, nicknamed "The Iron Horse" for his durability, played his entire 17-year baseball career for the New York Yankees (1923-1939). Gehrig set several major league records. He holds the record for most career grand slams (23). Gehrig is chiefly remembered for his prowess as a hitter, his consecutive games-played record. his career was cut short by amyotrophic lateral sclerosis (ALS), now commonly known in the United States and Canada as Lou Gehrig's disease. Over a 15-season span from 1925 through 1939, he played in 2,130 consecutive games, the streak ending only when Gehrig became disabled by the fatal neuromuscular disease that claimed his life two years later.