To mess with Wheelie, the Chopper Bunch persuades him to believe that he is greatly ill and needs to visit the doctor, despite being in perfect health.
After the death of his uncle, Wheelie inherits a junkyard which he plans to operate; however, Chopper is jealous of the acquired business and plans to scare Wheelie away and run it himself.
Rota Ree's uncle, a delivery truck, is unable to delivery his goods to their rightful owners because he is ill, so Wheelie promises to help out despite Chopper's desire to delay the deliveries.
Doctor Crankenstein, a psychotic scientist, creates a monster but needs the brain of an automobile in order to control it, so he hopes to capture either Wheelie or Chopper.
A vampire disguised as a race car and capable of transforming into a vampire bat relentlessly tries to steal oil away from other cars, including Wheelie.
Filling in for Rota Ree's dad, who is a street sweeper, Wheelie cleans the streets of Motor City, unbeknownst to the fact that Chopper is watching his every move.