The return to No-Limit Hold'em at the 2021 U.S. Poker Open sees Joe McKeehen at his second final table while Cary Katz holds the chip lead ahead of McKeehen, Adam Hendrix, Joey Weissman, Frank Funaro, Brock Wilson, and Vicent Bosca.
| Name | Type | Role | |
|---|---|---|---|
| Brent Hanks | Host | Himself - Commentator | |
| Jeff Platt | Host | Himself - Commentator | |
| Brock Wilson | Guest Star | ||
| Joe McKeehen | Guest Star | ||
| Vicent Bosca | Guest Star | ||
| Cary Katz | Guest Star | ||
| Frank Funaro | Guest Star | ||
| Adam Hendrix | Guest Star | ||
| Joey Weissman | Guest Star |