The game switches back to No-Limit Hold'em at the 2018 U.S. Poker Open with Event #3: $25,000 No-Limit Hold'em seeing Brent Hanks, Daniel Negreanu, Jake Schindler, Seth Davies, Keith Tilston, and Stephen Chidwick playing for the $374,000 first-place prize.
| Name | Type | Role | |
|---|---|---|---|
| Jeremy Ausmus | Host | Himself - Commentator | |
| Maria Ho | Host | Herself - Commentator | |
| Oliver 'Ali' Nejad | Host | Himself - Commentator | |
| Seth Davies | Guest Star | ||
| Keith Tilston | Guest Star | ||
| Brent Hanks | Guest Star | ||
| Stephen Chidwick | Guest Star | ||
| Daniel Negreanu | Guest Star | ||
| Jake Schindler | Guest Star |