Gia, a grieving writer, decides to write a book about women's desire. At the center is Lina, a housewife in Indiana; Sloane, a glamorous entrepreneur in the Northeast and Maggie, a waitress in North Dakota.
Lina flees from a stagnant marriage and a body of pain; she joins a women's group at Doctor Henry's, tries to reconnect with the love of her life, and begins a friendship with Gia.
Maggie summons the courage to tell her parents and the police about the relationship with her high school teacher that has been affecting her life ever since.
Jumping back in time, Gia struggles to write her book about sex in America; embarking on a love story of her own, Gia processes the pain of her own losses; she moves to Indiana and bonds with Lina.