Anne Robinson presents a special Doctor Who-themed edition of the quick-fire general knowledge quiz. David Tennant, John Barrowman, Camille Coduri, Noel Clarke, K9 and Tracy-Anne Oberman battle it out for intergalactic supremacy.
| Name | Type | Role | |
|---|---|---|---|
| Tracy-Ann Oberman | Guest Star | ||
| David Tennant | Guest Star | Contestant | |
| Tracy-Ann Oberman | Guest Star | Contestant | |
| John Barrowman | Guest Star | Contestant | |
| Andrew Hayden-Smith | Guest Star | Contestant | |
| Camille Coduri | Guest Star | Contestant | |
| Claire Rushbrook | Guest Star | Contestant | |
| Noel Clarke | Guest Star | Contestant | |
| John Leeson | Guest Star | Contestant (As K-9 [voice]) | |
| Nicholas Briggs | Guest Star | Contestant |