The Powerpuff Girls hate roaches. Roach Coach uses this to his advantage to take over Townsville. Can the Powerpuff Girls overcome their fear of roaches? After putting 3 criminals to jail those 3 criminals dress up as the Powerpuff Girls. Spreading crime wherever they go these impostors ruin the girls' reputation.
Him tries to break up the Powerpuff Girls through Bubbles' toy Octi. Can Blossom and Buttercup stop fighting in time to save the day. Trying hard to commit a crime The Amoeba Boys steal an orange. The Powerpuff Girls laugh in their faces and the sad Amoeba Boys stay out in the rain and spread the world's deadliest disease.
Buttercup falls in love with Ace, leader of The Gang Green Gang but instead of loving her back Ace tries to take advantage of her to take over Townsville. A squirrel trespasses on Fuzzy Lumpkins private property. Fuzzy chases him all the way into Townsville and goes crazy hurting all the citizens that stand in his way.
The Gang Green Gang makes prank calls to everyone in Townsville, but when the Mayor leaves his office The Gang Green Gang makes the ultimate prank calls by calling The Powerpuff Girls. The citizens of Townsville loves The Powerpuff Girls and its annoying Him, so Him turns everyone's love for the Powerpuff Girls into hate.
Blossom and Buttercup train in the danger room in the Professor's lab at high levels, but Bubbles' trains on the lower levels. Mad at her family for being treated like a baby, she tries to be hardcore like her sisters. Mojo kidnaps the Mayor and the Powerpuff Girls rescue him, but when the Mayor tries to get the story out of them each Powerpuff Girl has their own version.
An evil cat hypnotizes the Professor into stealing rare jewels to power a machine to brainwash the people of Townsville into being cat's slaves. The Mayor creates a commotion in Townsville about being re-elected as Mayor again, but he wakes up Fuzzy Lumpkins who get's annoyed. The people like Fuzzy and vote him Mayor.
A rainy day in Townsville becomes boring for the citizens of Townsville, so the Powerpuff Girls make the best out a terrible rainy day. Harold Smith finally gets paroled out of jail, and when he comes back to his adoring family they end up hating the Powerpuff Girls just as much as he does. Equipped with all sorts of high tech weapons the Smith's take their revenge out on the Utonium family.
Ms. Bellum seduces the Mayor to get some time off, but when something seems a miss the Powerpuff Girls investigate the situation. The Powerpuff Girls throw a slumber party and invites every girl in their school to come. By the time they give their invitation out to the last girl Mojo steals it and comes to the party dressed up as Mojesha.
The Professor gets a new job, and the Utonium family moves to the Town of Citysville. The Professor loves it, but the girls' don't and are having a hard time to adjust to the new changes. The Professor has to go out to an award's ceremony. He forgets to call the babysitter so he calls the Mayor who calls up Mojo Jojo to babysit.
Blossom and Buttercup have an argument thinking that brains or brawn is the best way to destroy a monster. Mojo Jojo turns the world into dogs again. The Powerpuff Girls come to the rescue wondering why Mojo does the same plan again. He tells them that he's found a fatal flaw in his old plan as he watches a video of his old plan.
After receiving a dollar from the Professor, Buttercup gets hooked and steals other people's teeth for the tooth fairy. Mojo Jojo, Princess Morebucks, Fuzzy Lumpkins, and Him all team up as The Beat Alls to defeat the Powerpuff Girls. All is going well until Mojo Jojo falls in love with Moko Jono who breaks up the Beat Alls.
Bubbles loves animals and the Professor is sick of her bringing them home, but when she brings home a baby whale the girls' try to hide him before the Professor comes home. The Gang Green Gang raids a mini mart eating all types of foods. When the Powerpuff Girls arrive they use their heat vision which causes a chain reaction which gives the Gang Green Gang super powers.
When the Mayor gets a craving for toast he discovers his toaster is broken so he gives it to the Professor to fix, but he accidentally discovers the Professor's secret stash of Chemical X, which the Mayor uses as a hair growth formula. After stealing a tangerine (orange) and watching it split up into different pieces the Amoeba Boys learn how to multiply and make duplicates of themselves.
The girls realize that the Professor is tired after preparing for his dissertation tomorrow, so when a burglar new to Townsville tries to rob them the girls try to stop him without waking up the Professor. The Professor tries to figure out just what kind of species Fuzzy Lumpkins is, but when he accidentally gets covered in mud and flowers it makes him look like a Lumpkin which Fuzzy falls in love with and tries to marry.
When the Powerpuff Girls try to stop Mojo from doing a crime an animal activist group comes to his rescue protesting that the Powerpuff Girls can't harm him because he's an endangered animal. When Ms. Keane gets sick she hires a substitute teacher named Mr.Green to run the class in her absence. Unfortunately because of his monstrous appearance the girls assume he's a bad guy and try to save their classmates from him.
The girls wake up to discover their bed is wet. Blossom, Bubbles, and Buttercup all deny to the incident, but they still wonder who did it. This destroys their confidence. Princess interrupts a battle between the Powerpuff Girls and the Rowdyruff Boys. She tries to join the Rowdyruff Boys but they reject her, so out of pity the girls let Princess become a Powerpuff Girl.
The Professor tries to teach the girls all about the history of silent movies and how they're much better than the movies of today by taking them to one. A new group of criminals -- a group of cute little animals -- robs Townsville blind. The girls try to stop them but, because of their innocent looks, the animal criminals have the advantage.
Back when Mojo Jojo tried to take over the world with primates, there was one monkey who didn't get his due - Mopey Popo. Now Mopey is back to try and be evil just as Mojo intended. When the Professor tries out his car, the Girls realize that this K.A.R.R. is taking the Professor away from them, both figuratively and literally.
After beating Fuzzy Lumpkins and other villains to a bloody pulp, Blossom and Bubbles start to think that their sister Buttercup goes a little bit too far when it comes to fighting crime. The Professor tells the girls all about his younger brother Eugene and how he was such a wild man back in the day.
When the Girls hear the Professor trying to make something out of sugar, spice, and everything nice, they are sure he's trying to create new little girls. The Mayor keeps having the same dream over and over again, but he never sees the end. Now it's up Girls to go into the Mayor's head and solve this mystery.
On Fathers Day (ironically) Mojo Jojo discovers that the Rowdyruff Boys are back to life. He also discovers that Him is now their dad and made them much better than he did. Angered by this Mojo Jojo and Him go into a competition to prove who is the more evil father. One day during a picnic, Bubbles get stung in the mouth by a bee. After a visit by the doctor, she is forbidden to speak for a week. Suddenly, when all the squirrels in Townsville get mad, Blossom and Buttercup are unable to do anything without Bubbles's special ability. Now it's up to Bubbles and Bullet to stop this crime.
A medium named Madame Argentina and her sidekick, Fred the Duck (he really is a duck), attempt to steal money from Townsville's citizens by offering to contact a dead relative for them. Professor Utonium is hosting a party for all the rich and famous people in Townsville, so Bubbles makes sure that she is the most beautiful of the girls by continually grooming herself. While doing this, she notices one of Octi's legs poking out from under the girls' bed, so she goes to pick him up to find that all that's there is one of Octi's legs! After waking up from the shock, she vows to exact revenge on the person who 'killed' Octi.
In Dance Pantsed, why is Mojo Jojo kidnapping a mathematician, an opera singer and a badger? To steal Chemical X, of course, and to finally take over Townsville. But when the Powerpuff Girls thwart his plan, he invents an evil video game called “Dance Pants R-EVILution” to control their minds and bodies to fulfill his evil plot! The Professor must visit his dark dancing past to save his girls so they can save all of Townsville!