The new students of Room 21 are told the frightening story of Charles Killian, an eccentric architect - Celia, the class bug girl, discovers she is second on the Killian hit list - Johnny Campbell has always had problems with is weight.
Things are getting tense in Room 21 - Lucy is the class serial texter - Owen has always struggled with motivation.
Lucy is brimming with confidence - Grace, the class bully, get in all sorts of trouble - Katie is becoming more and more paranoid about her fate at the hands of the Killian Curse.
Miles is forced to fight an alien. Te Aroha competes against a demon in a basketball game. Karl and Jack encounter a Wendigo.
Will is connected to a voodoo doll. Shane is attacked by a mummy on a school trip. Jen faces off with a shadow demon.
Chelsea battles with a vanity curse. Keith encounters his future self. Haley is attacked by a vampire on a blood bus.
Byron is chased by a car demon. Tabetha makes a school play about the curse. The surviving students face off against Killian.
It's a new year at Killian High and the crew are back, unfortunately so is the evil Charles Killian and he's out for revenge.
The last thing Room 21 needs is a school camp in the middle of nowhere.
Just who is helping the evil one claim the 21 souls he needs to walk the earth as a man again?
Miss deMorte is the coolest teacher and she's the first adult who actually believes there is a curse on Room 21.
Life is pretty hard for the class geek Shane.
Owen has to work at a local funeral home.
Killian has just two more souls to claim so he can once again walk the earth as a man, the traitor has to be one of only a handful of people, is it Billie?