The guests joining Jonathan this time include influential British singer-songwriter Craig David, award-winning comedian Katherine Ryan, and Stranger Things star Matthew Modine.
| Name | Type | Role | |
|---|---|---|---|
| James Menzies | Writer | ||
| Jonathan Ross | Writer | ||
| Kat Butterfield | Writer | ||
| Wet Leg | Musical Guest | ||
| Josh Jones | Guest Star | ||
| Craig David | Guest Star | ||
| Katherine Ryan | Guest Star | ||
| Matthew Modine | Guest Star | ||
| Oti Mabuse | Guest Star | ||
| Chris Howe | Director |