Jonathan's guests this time include former England cricket captain-turned-presenter Freddie Flintoff, The White Lotus actor Jason Isaacs, and the chart-topping Wet Leg performing.
| Name | Type | Role | |
|---|---|---|---|
| Jonathan Ross | Writer | ||
| James Farmer | Writer | ||
| Monica Long | Writer | ||
| Wet Leg | Musical Guest | ||
| Jason Isaacs | Guest Star | ||
| David Oyelowo | Guest Star | ||
| Sophie Willan | Guest Star | ||
| Rebel Wilson | Guest Star | ||
| Freddie Flintoff | Guest Star | ||
| Chris Howe | Director |