A research scientist, Dr. David Banner, haunted by his inability to save his wife from a deadly car accident, accidentally overdoses on gamma radiation. Now, whenever he becomes angry or outraged, he transforms into a powerful, green-skinned creature. A tabloid reporter, Jack McGee, begins to track the creature's trail of destruction.
Continuing his solitary flight, David Banner arrives in a small town where he saves the life of a young heiress, the target of a deadly conspiracy orchestrated by her stepmother and a corrupt physician. While working undercover to protect the girl and dismantle the plot, Banner must struggle to contain the beast within, especially when the arrival of reporter Jack McGee threatens to expose his secret to the world.
David boards a flight to visit another doctor whom he thinks has information that might help him with his problem. But, when the pilot and stewardess drugs the rest of the crew in an attempt to bail out of the airplane with stolen property, David and a young boy named Kevin try to land the jetliner.
Banner poses as a top doctor in physics to infiltrate a research complex, in order to access some gamma-ray equipment that may just be able to cure him of his green alter ego. He is about to start the attempt of reversing his condition when an earthquake strikes, blowing his cover, causing mass destruction and devastation, and setting off an impending core melt-down.
Banner is working in a tavern on the docks in Galveston, Texas, where he befriends the owner, a Union President's widow, whose husband was killed under suspicious circumstances. The woman is being pestered by a shady businessman, running to become the new President, to endorse his election campaign and he is willing to go to any lengths necessary to win the election.
David 'Benton' travels to Hawaii to meet Dr. Carolyn Fields (Mariette Hartley), a psychologist whose technique might help control the Hulk. However, Dr. Fields is in the terminal stages of a disease that the Hulk could help cure. With the pair working in close proximity, love begins to bloom with tragic results.
David works at a hardware store in a resort town, where business is receding. But when an argument with the store's depressed, widowed owner, Harlan, brings on the Hulk's appearance, Harlan and his friend quickly see the possibilities of what the publicity could do for the town. So they set about re-creating their own "monster" to draw in the tourists. But the scheme ends up endangering Harlan's own young daughter.
David is working as a gardener in a suburban school, where he befriends a boy whom he notices is covered in bruises. The school nurse informs David that it's not the first time it's happened, and he soon suspects that one of the boy's parents is abusing him. With no-one willing to listen or help, David sets about putting the situation right himself.
In a follow-up to "Another Path," David visits his friend Li Sung to hopefully find a cure to his transformations. But the old philosopher is now dying and looking for a successor in his practices; the candidate for his leadership is a student, a police officer coping with the recent murder of his father.
When David is arrested for vagrancy, he is placed in a police van where he encounters a man who envisions himself as the deceased writer Ernest Hemmingway. But when a fight provokes David's transformation into the Hulk, our hero escapes, inadvertently freeing the mentally ill man in the process. David must help find the man before he hurts himself or someone else.
In Atlantic City, FBI agents catch David with contraband shipments belonging to a gang of thieves, and insist that he be an informant until the gang is apprehended. David has no choice but to cooperate with both sides since both are aware of who he is; the FBI agents know that he is David Banner, while the elderly woman, who is one of the thieves, is aware that he becomes the Hulk.
Years after the end of the original series, David Banner continues his wandering search for a cure for the condition that turns him into the Hulk. He reunites with former colleague Don Blake, unaware of his mystical connection to Thor. When a criminal organization threatens their lives, Banner is forced to unleash the Hulk once again, marking the character’s return after the series finale.
Falsely accused of assault, Dr. David Banner is arrested and placed on trial, facing the possibility of a long prison sentence. Blind attorney Matt Murdock takes on his defence, while secretly operating as the vigilante Daredevil. As the courtroom battle unfolds, Banner’s struggle to control the Hulk leads to a dangerous confrontation with criminal mastermind Wilson Fisk.
In his final attempt to free himself from the curse of the Hulk, Dr. David Banner becomes involved in a dangerous international espionage mission that may finally lead to a cure. As forces close in and the stakes rise, Banner faces an ultimate sacrifice, bringing his tragic journey to a definitive and emotional conclusion.