自幼沉迷研究草藥的李時珍（林文龍飾）與冬青（葉璇飾）互相傾慕，可惜他與吳慕榕（李詩韻飾）早有婚約在先。珍本打算科舉後與榕解除婚約並向青表白，豈料珍應考回鄉後，青誤打誤撞，答應了珍兄長果珍（艾威飾）的提親，珍不得已娶榕為妻。其後，珍拜奇醫小地藏為師，原來他正是青之養父。 珍發現古代的醫書謬誤甚多，而假藥亦充斥市場，因而立志撰寫《本草綱目》。珍獲楚王推薦入太醫院當太醫，編寫《本草綱目》一事，因珍開罪了權貴嚴嵩而受到阻撓，珍更從此展開了逃亡的生涯，期間太醫院高材生龐憲（馬國明飾）一直追隨在側。 皇上終於查明真相，珍倖免於難，自此一邊隱世行醫，一邊研究草藥，決意窮一生精力完成《本草綱目》。
| Season | From | To | Episodes |
|---|---|---|---|
| All Seasons | |||
| Specials | 0 | ||
| Season 1 | November 2005 | 25 | |
| Unassigned Episodes | 0 |
| Season | From | To | Episodes |
|---|---|---|---|
| Unassigned Episodes | 25 |
| Season | From | To | Episodes |
|---|---|---|---|
| Season 1 | 0 | ||
| Unassigned Episodes | 25 |
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