Host David Yetman joins local herpetologists (reptile and amphibian researchers) in their various separate quests to learn more about the many venomous creatures that call the Sonoran Desert home, most notably, the rattlesnake. During the day, they track Tiger Rattlesnakes by using radio implants before heading up to the mountains to observe Black Rattlesnake dens. One night, they go road hunting for sidewinders and encounter lizards, tarantulas, and desert toads. Another night, they study the impact some urban developments have on the movements of Gila Monsters.