Laura’s 24-year old cat Pun’kin is old and smelly. George realizes it’s time to put the cat to sleep but he’s afraid to talk to Laura about it. Laura notices that George isn’t as amorous as he used to be and is afraid she’s the one that’s old and smelly. While Laura tries to solve her feminine hygiene problems, George breaks Jack Kevorkian out of prison to help kill the cat.
George decides to get tough on drugs. The plan is to make an example of the one-millionth drug offender by arresting him on national television. Former First Lady Barbara Bush is on hand to participate in the event and make her daughter-in-law’s life miserable. Looking to escape the tension between the two women in his life, George drops ecstasy, mistaking it for aspirin, and the anti-drug event turns into a rave.