A families' escaped pet python kills their young daughter. Chuck searches the Everglades for a nasty Burmese python. Ernie must tear apart fences to capture an aggressive red tail boa loose in a suburban neighborhood.
An alligator blocking a roadway tries to rip off Lt. Lisa Wood's leg. A deadly rattlesnake strikes out from underneath thick brush, and when the Venom One team gets called out to a dog rescue, they find not one, but three killer snakes.
Chuck and Ernie go to Costa Rica to search for a deadly pit viper called a black-headed bushmaster.