Dante is reunited with an old bounty hunter friend named MacDuff who is dying from a brain tumor but still offers to assist Dante on a final mission. Dante's partner Lucretia is tasked by her mysterious father Darius to capture a renegade geneticist named Eccleston who may hold the key to the so-called "Divinity Cluster" — a sequence of human genes believed implanted by aliens that when activated unlock incredible superhuman abilities.