During high school orientation Peter's life is forever changed. A new era of Spider-Man begins here!
| Name | Type | Role | |
|---|---|---|---|
| Jeff Trammell | Writer | ||
| Robin Atkin Downes | Guest Star | Doctor Strange | |
| Erica Luttrell | Guest Star | Emma / Mrs. Lincoln | |
| Kari Wahlgren | Guest Star | Mrs. Eberhardt | |
| Phil LaMarr | Guest Star | Mr. Taylor / Mr. Lincoln | |
| Zeno Robinson | Guest Star | Mr. Campbell | |
| Ogie Banks | Guest Star | Pizza Shop Owner | |
| Kellen Goff | Guest Star | Symbiotic Alien | |
| Mel Zwyer | Director |