Outstanding film and TV performances are honored at the 16th annual gala from the Shrine Exposition Center in Los Angeles. Sandra Bullock presents the Life Achievement Award to Betty White; the art of comic acting is saluted via a film montage. Presenters include Alec Baldwin; George Clooney; Meryl Streep; Jane Lynch; Michelle Monaghan; Chris O'Donnell; Anna Paquin; and Stanley Tucci.