Sketches include Rikers Island, Liquorville, WXPD News, Three-Way (Digital Short), What's That Name?, Merry-Go-Love Tunnel, Secret Word and The Barry Gibbs Talk Show. Lady Gaga performs "The Edge of Glory", "Judas" and "Born This Way".
| Name | Type | Role | |
|---|---|---|---|
| Lady Gaga | Musical Guest | ||
| Justin Timberlake | Host | ||
| Jimmy Fallon | Guest Star | ||
| Susan Sarandon | Guest Star | ||
| Bradley Cooper | Guest Star | ||
| Patricia Clarkson | Guest Star |