Sketches include "Bush Responds to Criticism," "Nelson's Baby Toupees," "Jamba Juice," "Larry King Live," "The Couple That Should Be Divorced," "Belated Black History Moment" (cartoon), "Art Dealers and the College Boyfriend," "Sheldon's Bar Mitzvah," "The Real Natalie" (film), and "RAD 3000." Fall Out Boy performed "Dance Dance" and "Sugar, We're Going Down."
| Name | Type | Role | |
|---|---|---|---|
| Natalie Portman | Guest Star | ||
| Pete Wentz | Guest Star | ||
| Tia Dionne Hodge | Guest Star | ||
| Desmond Harrington | Guest Star | ||
| Andrew Hurley | Guest Star | ||
| Dennis Haysbert | Guest Star | ||
| Patrick Stump | Guest Star | ||
| Ruby Jerins | Guest Star | ||
| Joe Trohman | Guest Star | ||
| Fall Out Boy | Guest Star | ||
| Beth McCarthy-Miller | Director |