The Turtles end up facing a new and dangerous threat in their beloved city as Baron Draxum, Huginn, and Muninn gather some of their toughest mutant enemies like Meat Sweats, Hypno-Potamus, Warren Stone, Repo Mantis, and the Sando Brothers in a plot to destroy them.
| Name | Type | Role | |
|---|---|---|---|
| Jesse Gordon | Writer | ||
| Vladimir Radev | Producer | ||
| Maurice LaMarche | Guest Star | Foot Brute | |
| Fred Tatasciore | Guest Star | Repo Mantis | |
| Paul Scheer | Guest Star | Ben Sando | |
| John Cena | Guest Star | Baron Draxum | |
| John Lydon | Guest Star | Meat Sweats | |
| Jason Mantzoukas | Guest Star | Carl Sando | |
| Timothy Simons | Guest Star | Huginn | |
| Rhys Darby | Guest Star | Hypno-Potamus | |
| Thurop Van Orman | Guest Star | Todd Capybara | |
| Sam Richardson | Guest Star | Muninn | |
| Eric Bauza | Guest Star | Splinter/Lou Jitsu | |
| Rob Paulsen | Guest Star | Foot Lieutenant | |
| John Michael Higgins | Guest Star | Warren Stone | |
| Andy Suriano | Executive Producer | Co-Executive Producer | |
| Ant Ward | Executive Producer | Co-Executive Producer | |
| Sebastian Montes | Director |