The Turtles look for a way to eliminate New York City's Oozesquito problem before more mutants are made. This plot brings them into conflict with Big Mama in her plot to make mutants to fight for her entertainment in the Battle Nexus, which is soon joined by Baron Draxum.
| Name | Type | Role | |
|---|---|---|---|
| Russ Carney | Writer | ||
| Ron Corcillo | Writer | ||
| Jesse Gordon | Writer | ||
| Ian Busch | Writer | ||
| Vladimir Radev | Producer | ||
| Fred Tatasciore | Guest Star | Owl Bellhop, Gus | |
| Sam Richardson | Guest Star | Muninn | |
| Eric Bauza | Guest Star | Fox Bellhop | |
| Timothy Simons | Guest Star | Huginn | |
| Dave Foley | Guest Star | Bellhop | |
| Ian Busch | Guest Star | Laundry Yokai | |
| Lena Headey | Guest Star | Big Mama | |
| Nolan North | Guest Star | Otter Bellhop, Octopus Elevator Operator | |
| John Cena | Guest Star | Baron Draxum | |
| Andy Suriano | Executive Producer | Co-Executive Producer | |
| Ant Ward | Executive Producer | Co-Executive Producer | |
| Jamie Vickers | Director | ||
| Abe Audish | Director | ||
| Brendan Clogher | Director |